==inizio objective==
Lichen sclerosus (LS) is a disease of unknown etiology that affects the genitals.
It is characterized by atrophy of the epidermis.
This disease is characterized by atrophy of the mucosa of the glans and prepuce leading to trauma during intercourse, difficulty in preputial mobility, erectile dysfunction, phimosis and paraphimosis and urethral stricture [1].
==fine objective==
==inizio methodsresults==
7 patients (pts) with LS and urethral stricture were enrolled for this study. Patient mean was age 54 years.
All of the patients underwent physical examination, uroflowmetry, retrograde and voiding urethrography in order to evaluate the stricture. The mean Qmax was 5 ml/sec. Mean stricture length was 4.2 cm.
All pts underwent one-stage urethroplasty with buccal/labial mucosa graft.
A midline longitudinal, ventral incision was made starting from the urethral meatus. The penile urethra was exposed with minimal dissection. The urethra was opened along its ventral surface under the guidance of the guide wire, previously inserted. The urethra was spatulated up to normal caliber and pink urethral mucosa. The entire urethral plate affected by the LS was removed. Then the buccal mucosa graft was taken from the cheek an then it was spatulated in order to remove fatty tissues under the mucosa. Then it was sutured on the urethral plate with two lateral running sutures and many single stiches on the whole graft in 5.0 Vicryl suture.
The neo-urethra was incised laterally and tubularized with 5.0 Vicryl suture.
The glans was reconstruct on the tubularized urethra. Dartos fascia and skin were closed. A sovrapubic catheter and a 10 Fr urethral stent were inserted and left for two weeks post-operatively.
Pts were discharged from the clinic 2 days after surgery.
==fine methodsresults==
==inizio results==
At 1 year follow-up all pts underwent uroflowmetry in order to assess the voiding.
One patient needed a second surgery (Meatoplasty) in order to open the meatus.
Mean Qmax was 15 ml/sec. All pts were satisfied with the functional and aesthetic results of the surgery
==fine results==
==inizio discussions==
In pts with penile strictures caused by LS, the penis is fully involved in the disease : glans, meatus, skin, fibrotic dartos. For these pts two-stage repair would be less risky and for this reason it is normally recommended the two-stage repair [2]. On the other hands pts, between the two stages, complain about the appearance of the penis that is open ventrally. Some pts don’t make any physiotherapy post-operatively leading to scarring tissue on the urethral plate. The caliber of the neo-urethra should be wider than normal caliber due the fact that it will reduce after a while. At moment buccal mucosa graft represent the best tissue to replace the urethra.
==fine discussions==
==inizio conclusion==
Penile stricture with LS is a complex disease that needs to be treated with urethroplasty with buccal mucosa graft. This procedure in one-stage can give a good results just if the caliber of the neo-urethra is wide enough.
This procedure is the only technique that can treat LS and penile strictures.
==fine conclusion==
==inizio reference==
1) Kulkarni S, Kulkarni J, Surana S, Joshi PM. Management of Panurethral Stricture. Urol Clin North Am. 2017 Feb;44(1):67-75
2) Angulo JC, Arance I, Esquinas C, Nikolavsky D, Martins N, Martins F. Treatment of long anterior urethral stricture associated to lichen sclerosus. Actas Urol Esp. 2016 Nov 2.
==fine reference==